Mechanical Ventilation Triggers Hippocampal Apoptosis by Vagal and Dopaminergic Pathways

Rationale: Critically ill patients frequently develop neuropsychological disturbances including acute delirium or memory impairment. The need for mechanical ventilation is as a risk factor for these adverse events, but a mechanism that links lung stretch and brain injury has not been identified. Objetives: To identify the mechanisms that lead to brain dysfunction during mechanical ventilation. Methodsurbances including acute delirium or memory impairment. The need for mechanical ventilation is as a risk factor for these adverse events, but a mechanism that links lung stretch and brain injury has not been identified. Objetives: To identify the mechanisms that lead to brain dysfunction during mechanical ventilation. Methods...

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