This Viewpoint discusses ways the US Preventive Services Task Force (USPSTF) is working to identify contributions of systemic racism to differences in health outcomes, and to develop evidence-based recommendations to mitigate the effects of social, economic, and structural disadvantage on disease and its related sequelae.

This Viewpoint uses examples of recommendations for race-based pharmacogenetic testing to discuss flaws and inconsistencies with race and ethnicity as surrogates for biology, and the consequences of those deficiencies for clinical decision-making.

This randomized clinical trial compares the effects of 3 doses of bamlanivimab monotherapy (700 vs 2800 vs 7000 mg) vs combination bamlanivimab and etesevimab vs placebo on change in day 11 severe acute respiratory syndrome coronavirus 2 viral load in patients with mild to moderate coronavirus disease 2019 (COVID-19).

In this issue of JAMA, Gottlieb et al report the findings of the ongoing BLAZE-1 (Blocking Viral Attachment and Cell Entry with SARS-CoV-2 Neutralizing Antibodies) trial, a randomized, phase 2/3 clinical trial of antispike neutralizing monoclonal antibody treatment among 577 outpatients with mild or moderate coronavirus disease 2019 (COVID-19). This report represents the final analysis of the phase 2 portion of this trial and included 5 cohorts (3 groups with varying doses of bamlanivimab monotherapy, 1 group with a combination therapy of bamlanivimab and etesevimab, and a placebo group). The findings for the difference between each of the 3 monotherapy groups compared with the placebo group for the primary end point of change in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) log viral load at day 11 from baseline were not statistically significant, but were statistically significantly different for the primary end point for the combination therapy group compared with the placebo group.

This study assesses changes in abortions performed and at what gestational age following a Texas order postponing non–medically necessary surgeries due to the COVID-19 pandemic compared with abortions performed during the same months in 2019.

Updated recommendations for treating gonorrhea aim to combat rising drug resistance.

More than 81?000 people died of drug overdoses in the US between June 2019 and May 2020, a record-breaking number that CDC officials suggested is related to the coronavirus disease 2019 (COVID-19) pandemic.

This Viewpoint evaluates Biden’s health care proposals to help reduce the cost burden on patients with cancer should they be enacted legislatively.

This Viewpoint suggests that the COVID-19 pandemic provides an opportunity to build trust in science and update federal agencies to improve public health and poses questions and offers recommendations for consideration.

This narrative review summarizes the pathophysiology, diagnosis, and treatment of osteoarthritis (OA) of the hip and knee, including use of structured exercise, acetaminophen and NSAIDs, corticosteroid injections, and surgery to manage symptoms.

In this narrative medicine essay an internal medicine hospitalist explores what the new diagnosis of breast cancer means for her professional identity and considers how the COVID-19 pandemic facilitates the hiding of serious illness but also complicates disclosing the news to colleagues and friends.

Months we all gelled—pills, probes, we pried, we eyed you. Scouring echoes mottled like the Moon, I found your face. Eighteen weeks in, too soon to fly your flawed cocoon, our doctor spied your two feet thrust through. Though your mother tried a banked bed, buoying you, her water broke. The wits I lacked, her nurses lent. “Just stroke her hair, don't look,” they pled—so I complied. But when your cord got clamped, before you ceased your windless breaths, I should've made a stand: amidst those steel stirrups, laying a hand that said, “We love you Lincoln. Go in peace.” What now? Stroke prints inked by lifeless feet then? Too late. You'll never be that close again.

This JAMA Patient Page explains the medications (naltrexone, acamprosate, disulfiram) and behavioral treatments (cognitive behavior therapy [CBT]) used to manage alcohol use disorder.

This noninferiority trial compares the effects of a restrictive (hemoglobin ?8 g/dL) vs liberal (hemoglobin ?10 g/dL) transfusion strategy on 30-day cardiovascular events among adults with acute myocardial infarction (AMI) and anemia (hemoglobin 7-10 g/dL).

This population epidemiology study describes the prevalence of bicuspid aortic valve (BAV) and BAV subtypes, and of accompanying enlarged aortic diameter or coarctation, in Danish newborns born in Copenhagen 2016-2018.

This randomized trial compares the effects of high-intensity interval training, moderate continuous training, and guideline-based physical activity on change in peak oxygen consumption (V?o2) in patients with heart failure with preserved ejection fraction (HFpEF).

This Medical Letter review reproduces a Table summarizing key information about drugs for osteoarthritis published as part of a comprehensive review on the topic.

In Reply Mr Li and Dr Wang highlight valuable examples of regulation from other industries, including banking and insurance. We agree that best practices from these industries provide lessons for health care and that health system–level algorithmic stewardship should complement clear guidance and oversight from those with regulatory authority.

In Reply In response to our recent article about trends in BP control among US adults, Dr Kovell and colleagues emphasize the importance of hypertension control to reduce cardiovascular disease mortality in women and to prevent maternal morbidity and mortality. They note that women had a larger reduction in BP control between 2013-2014 and 2017-2018 compared with men.