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Error in Results Section

Mar, 16/02/2021 - 01:00
The Original Investigation titled “Effect of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy With Uterosacral Ligament Suspension on Treatment Failure in Women With Uterovaginal Prolapse: A Randomized Clinical Trial,” published in the September 17, 2019, issue of JAMA, included errors in the data in the Results section. The data have been corrected in the Results section, including in the tables and figures. (All other information in the Results section was correct and is unchanged.)

Hospital Clowns Ease Children’s Symptoms, Review Shows

Mar, 16/02/2021 - 01:00
This Medical News article describes a review of studies that examine whether hospital clowns can help alleviate pediatric patients’ symptoms such stress, anxiety, and pain.

Recalibrating the Use of Race in Medical Research

Mar, 16/02/2021 - 01:00
This Viewpoint reviews the way race has been used and misused in medical research and urges careful consideration by investigators of how its use might ameliorate or worsen health inequalities.

Accounting for Systemic Racism In USPSTF Recommendation Statements

Mar, 16/02/2021 - 01:00
This Viewpoint discusses ways the US Preventive Services Task Force (USPSTF) is working to identify contributions of systemic racism to differences in health outcomes, and to develop evidence-based recommendations to mitigate the effects of social, economic, and structural disadvantage on disease and its related sequelae.

Race and Pharmacogenomics—Personalized Medicine or Misguided Practice?

Mar, 16/02/2021 - 01:00
This Viewpoint uses examples of recommendations for race-based pharmacogenetic testing to discuss flaws and inconsistencies with race and ethnicity as surrogates for biology, and the consequences of those deficiencies for clinical decision-making.

Effect of Bamlanivimab Alone vs With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19

Mar, 16/02/2021 - 01:00
This randomized clinical trial compares the effects of 3 doses of bamlanivimab monotherapy (700 vs 2800 vs 7000 mg) vs combination bamlanivimab and etesevimab vs placebo on change in day 11 severe acute respiratory syndrome coronavirus 2 viral load in patients with mild to moderate coronavirus disease 2019 (COVID-19).

Neutralizing Monoclonal Antibody for Mild to Moderate COVID-19

Mar, 16/02/2021 - 01:00
In this issue of JAMA, Gottlieb et al report the findings of the ongoing BLAZE-1 (Blocking Viral Attachment and Cell Entry with SARS-CoV-2 Neutralizing Antibodies) trial, a randomized, phase 2/3 clinical trial of antispike neutralizing monoclonal antibody treatment among 577 outpatients with mild or moderate coronavirus disease 2019 (COVID-19). This report represents the final analysis of the phase 2 portion of this trial and included 5 cohorts (3 groups with varying doses of bamlanivimab monotherapy, 1 group with a combination therapy of bamlanivimab and etesevimab, and a placebo group). The findings for the difference between each of the 3 monotherapy groups compared with the placebo group for the primary end point of change in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) log viral load at day 11 from baseline were not statistically significant, but were statistically significantly different for the primary end point for the combination therapy group compared with the placebo group.

Changes in Abortion in Texas Following an Executive Order Ban During the Coronavirus Pandemic

Mar, 16/02/2021 - 01:00
This study assesses changes in abortions performed and at what gestational age following a Texas order postponing non–medically necessary surgeries due to the COVID-19 pandemic compared with abortions performed during the same months in 2019.

Updated Recommendations for Gonorrhea Treatment

Mar, 09/02/2021 - 01:00
Updated recommendations for treating gonorrhea aim to combat rising drug resistance.

Accelerated Overdose Deaths Linked With COVID-19

Mar, 09/02/2021 - 01:00
More than 81?000 people died of drug overdoses in the US between June 2019 and May 2020, a record-breaking number that CDC officials suggested is related to the coronavirus disease 2019 (COVID-19) pandemic.

Cancer Care Under the Biden Administration

Mar, 09/02/2021 - 01:00
This Viewpoint evaluates Biden’s health care proposals to help reduce the cost burden on patients with cancer should they be enacted legislatively.

COVID-19 Pandemic, an Opportunity for a More Successful Future for Science and Public Health

Mar, 09/02/2021 - 01:00
This Viewpoint suggests that the COVID-19 pandemic provides an opportunity to build trust in science and update federal agencies to improve public health and poses questions and offers recommendations for consideration.

JAMA

Mar, 09/02/2021 - 01:00

Diagnosis and Treatment of Hip and Knee Osteoarthritis

Mar, 09/02/2021 - 01:00
This narrative review summarizes the pathophysiology, diagnosis, and treatment of osteoarthritis (OA) of the hip and knee, including use of structured exercise, acetaminophen and NSAIDs, corticosteroid injections, and surgery to manage symptoms.

Donning and Doffing—Hiding Cancer Treatment in Plain Sight

Mar, 09/02/2021 - 01:00
In this narrative medicine essay an internal medicine hospitalist explores what the new diagnosis of breast cancer means for her professional identity and considers how the COVID-19 pandemic facilitates the hiding of serious illness but also complicates disclosing the news to colleagues and friends.

To a Firstborn Son

Mar, 09/02/2021 - 01:00
Months we all gelled—pills, probes, we pried, we eyed you. Scouring echoes mottled like the Moon, I found your face. Eighteen weeks in, too soon to fly your flawed cocoon, our doctor spied your two feet thrust through. Though your mother tried a banked bed, buoying you, her water broke. The wits I lacked, her nurses lent. “Just stroke her hair, don't look,” they pled—so I complied. But when your cord got clamped, before you ceased your windless breaths, I should've made a stand: amidst those steel stirrups, laying a hand that said, “We love you Lincoln. Go in peace.” What now? Stroke prints inked by lifeless feet then? Too late. You'll never be that close again.

Patient Information: Treatment of Alcohol Use Disorder

Mar, 09/02/2021 - 01:00
This JAMA Patient Page explains the medications (naltrexone, acamprosate, disulfiram) and behavioral treatments (cognitive behavior therapy [CBT]) used to manage alcohol use disorder.

Effect of Restrictive vs Liberal Blood Transfusion Strategy on Adults With Myocardial Infarction and Anemia

Mar, 09/02/2021 - 01:00
This noninferiority trial compares the effects of a restrictive (hemoglobin ?8 g/dL) vs liberal (hemoglobin ?10 g/dL) transfusion strategy on 30-day cardiovascular events among adults with acute myocardial infarction (AMI) and anemia (hemoglobin 7-10 g/dL).

Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Danish Newborns

Mar, 09/02/2021 - 01:00
This population epidemiology study describes the prevalence of bicuspid aortic valve (BAV) and BAV subtypes, and of accompanying enlarged aortic diameter or coarctation, in Danish newborns born in Copenhagen 2016-2018.

Intensity of Physical Activity and Peak Oxygen Consumption in Patients With Heart Failure

Mar, 09/02/2021 - 01:00
This randomized trial compares the effects of high-intensity interval training, moderate continuous training, and guideline-based physical activity on change in peak oxygen consumption (V?o2) in patients with heart failure with preserved ejection fraction (HFpEF).