Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.

This JAMA Guide to Statistics and Medicine explains immortal time bias, an error in estimating the association between an exposure and an outcome that results from misclassification or exclusion of time intervals; explains how this misclassification or exclusion can occur; and presents approaches to minimize or avoid immortal time bias.

In an updated safety communication, the FDA recommended that clinicians who perform laparoscopic power morcellation for gynecologic procedures should do so with a legally marketed containment system to prevent unsuspected cancer from spreading within the abdomen and pelvis.

The FDA has issued draft recommendations to help developers of antisense oligonucleotide (ASO) therapies for rare, debilitating genetic diseases to conduct human trials with a single participant, known as n-of-1 trials.

The first generic version of injectable glucagon for treating severe hypoglycemia has received FDA approval. Packaged as an emergency kit with a 1-mg dose, the drug treats extremely low blood glucose in patients with diabetes. The drug is also indicated to slow bowel motion during radiological examinations to provide a clear picture of abdominal and pelvic areas.

Historically, the focus on the development of atherosclerotic cardiovascular disease has been on individual risk factors. These factors, which are associated with increased risk of myocardial infarction and stroke, were identified in the Framingham Study and other longitudinal observational studies of adults. The traditional risk factors are hypertension, dyslipidemia, obesity, diabetes, and cigarette smoking. Subsequently, other potential risk factors, such as inflammation and insulin resistance, have been included in the discussion. The recognition of risk factors was a substantial advance because it provided clinical targets for intervention. Subsequent research has demonstrated that interventions that result in improvement in risk factors do reduce the risk of morbidity and mortality from cardiovascular disease. Research has shown that these risk factors are present in children and adolescents and are associated with increased prevalence and severity of atherosclerotic lesions in individuals who had autopsies after death due to various causes and trauma.

The Original Investigation titled “Effect of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy With Uterosacral Ligament Suspension on Treatment Failure in Women With Uterovaginal Prolapse: A Randomized Clinical Trial,” published in the September 17, 2019, issue of JAMA, included errors in the data in the Results section. The data have been corrected in the Results section, including in the tables and figures. (All other information in the Results section was correct and is unchanged.)

This Medical News article describes a review of studies that examine whether hospital clowns can help alleviate pediatric patients’ symptoms such stress, anxiety, and pain.

This Viewpoint reviews the way race has been used and misused in medical research and urges careful consideration by investigators of how its use might ameliorate or worsen health inequalities.

This Viewpoint discusses ways the US Preventive Services Task Force (USPSTF) is working to identify contributions of systemic racism to differences in health outcomes, and to develop evidence-based recommendations to mitigate the effects of social, economic, and structural disadvantage on disease and its related sequelae.

This Viewpoint uses examples of recommendations for race-based pharmacogenetic testing to discuss flaws and inconsistencies with race and ethnicity as surrogates for biology, and the consequences of those deficiencies for clinical decision-making.

This randomized clinical trial compares the effects of 3 doses of bamlanivimab monotherapy (700 vs 2800 vs 7000 mg) vs combination bamlanivimab and etesevimab vs placebo on change in day 11 severe acute respiratory syndrome coronavirus 2 viral load in patients with mild to moderate coronavirus disease 2019 (COVID-19).

In this issue of JAMA, Gottlieb et al report the findings of the ongoing BLAZE-1 (Blocking Viral Attachment and Cell Entry with SARS-CoV-2 Neutralizing Antibodies) trial, a randomized, phase 2/3 clinical trial of antispike neutralizing monoclonal antibody treatment among 577 outpatients with mild or moderate coronavirus disease 2019 (COVID-19). This report represents the final analysis of the phase 2 portion of this trial and included 5 cohorts (3 groups with varying doses of bamlanivimab monotherapy, 1 group with a combination therapy of bamlanivimab and etesevimab, and a placebo group). The findings for the difference between each of the 3 monotherapy groups compared with the placebo group for the primary end point of change in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) log viral load at day 11 from baseline were not statistically significant, but were statistically significantly different for the primary end point for the combination therapy group compared with the placebo group.

This study assesses changes in abortions performed and at what gestational age following a Texas order postponing non–medically necessary surgeries due to the COVID-19 pandemic compared with abortions performed during the same months in 2019.

Updated recommendations for treating gonorrhea aim to combat rising drug resistance.

More than 81?000 people died of drug overdoses in the US between June 2019 and May 2020, a record-breaking number that CDC officials suggested is related to the coronavirus disease 2019 (COVID-19) pandemic.

This Viewpoint evaluates Biden’s health care proposals to help reduce the cost burden on patients with cancer should they be enacted legislatively.

This Viewpoint suggests that the COVID-19 pandemic provides an opportunity to build trust in science and update federal agencies to improve public health and poses questions and offers recommendations for consideration.

This narrative review summarizes the pathophysiology, diagnosis, and treatment of osteoarthritis (OA) of the hip and knee, including use of structured exercise, acetaminophen and NSAIDs, corticosteroid injections, and surgery to manage symptoms.